Sex sonic the hedgehog

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This inactive state of the hedgehog signaling pathway is necessary, otherwise it triggers the ectopic appearance of fetal Leydig cells Barsoum et al. Nat Genet. Biochem Biophys Res Commun. A pattern has emerged in which the hedgehog signal emanates from the epithelium and signals through its downstream components in the mesenchyme. Thus, the hedgehog signaling pathway represents a conserved mechanism of external genitalia development.

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Identification of Indian hedgehog as a progesterone-responsive gene in the murine uterus.

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Epithelial—mesenchymal communication via the hedgehog signaling pathway seems to be maintained in the adult reproductive tract, similar to that of the fetal stage. However, after birth, all three Hedgehog ligands are detected Russell et al. Mutations affecting segment number and polarity in Drosophila. Copyright notice. Therefore, it does not appear as though the hedgehog signaling pathway acts upon the testis vascular network. Chromosome localization of the core components of the hedgehog signaling pathway in various species.

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